Duovir (Lamivudine/Zidovudine)

Duovir Tablet is a nucleoside simple. It is utilized in blend with different drugs to treat HIV contamination. It works by meddling with the development of the HIV contamination.

On utilizing this drug you may encounter reactions, for example, queasiness, joint agony, trouble dozing, loose bowels, hack, discombobulation, swelling of the mouth, cerebral pain, decreased craving, shortcoming, regurgitating, obscuring of the pee, deadness, mental/state of mind issue, ear torment, irritation, sore throat and chest torment. On the off chance that your responses endure or decline after some time look for the assistance of your social insurance supplier immediately.

Before utilizing this drug tell your specialist on the off chance that: you are susceptible to any fixing contained inside Duovir Tablet, you are taking some other prescriptions particularly emtricitabine and zalcitabine, you have expanded liver, large amounts of lactic corrosive, irregular liver working, muscle issues, kidney issues, lactic acidosis, nerve issue, pancreas issue, you are overweight, you are pregnant or are intending to end up pregnant or are nursing a child.

The dose for this medicine ought to be founded on your restorative history and current condition. The standard portion in grown-ups for HIV disease is around 150 mg twice every day or 300 mg once day by day.

Data given here depends on the salt and substance of the prescription. Impact and employments of medication may fluctuate from individual to individual. It is advicable to counsel a HIV Specialist before utilizing this drug.

Duovir tablets are a combination treatment for Human Immunodeficiency Virus (HIV) infection in patients with or without acquired immunodeficiency syndrome or AIDS. HIV impairs the immune system by attacking specific immune cells called CD4 cells that are involved in fighting infection and this can lead to opportunistic life-threatening infection. Duovir tablets help prevent or slow down the ability of HIV to replicate, which keeps the amount virus down to a low level and this results in an increase in CD4 cell numbers, so that the immune system can recover reducing the risk of disease progression.

Duovir tablets contain a combination of two antiretroviral drugs lamivudine and zidovudine, which both belong to class of drugs known as nucleoside analogue reverse transcriptase inhibitors (NRTI) that are only effective against retroviruses (RNA virus) like HIV. A nucleoside is a building block of DNA that is needed by the virus to replicate, and nucleoside analogues, like lamivudine and zidovudine in Duovir tablets, become incorporated into the DNA that is copied from the virus RNA by an enzyme called reverse transcriptase. This blocks the action of reverse transcriptase and terminates the viral DNA chain so that it cannot become integrated into the DNA of the infected immune cell, which means that no more HIV can be produced. Lamivudine is highly synergistic with zidovudine, which means that it increases the effectiveness of zidovudine so that the combination of these two antiretroviral drugs in Duovir tablets slow down the replication of HIV within your body but cannot prevent the spread of the infection to others.

If you have an allergy to lamivudine or any other part of this drug. Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.

• Allergy

This medicine is not recommended for use in patients with a known allergy to lamivudine, zidovudine, or any other inactive ingredients present along with these medicines.

• Renal impairment

This medicine is not recommended for use in patients with creatinine clearance less than 50 ml/min due to the increased risk of serious adverse effects.

• Liver impairment

This medicine is not recommended for use in patients with liver function impairment due to the increased risk of worsening of the patient’s condition.

• Missed Dose

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up for the missed dose.

• Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.

• Chills and fever
• Sore throat
• Pale skin
• Unusual tiredness
• Diarrhea
• Rash
• Nausea and Vomiting
• Difficulty with bowel movements
• Headache
• Weight loss
• Heartburn
• Abdominal and stomach cramps
• Loss of appetite
• Depression
• Stuffy nose
• Muscle pain
• Difficulty in falling asleep
• Cough

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