Endace 40 mg (Megestrol Acetate)

What is Endace 40 mg?

Endace -40Mg Tablet is a synthetic form of the naturally occurring hormone progesterone which is most commonly used as an appetite stimulating agent in the treatment of anorexia and cachexia associated with HIV/AIDS. It is also used as an antineoplastic agent in the palliate treatment of breast cancer or endometrial cancer.

It mimics the action of progesterone by binding to progesterone receptors and stimulates the expression of target genes. Its antitumor properties are because of its progesterone agonist activity, which leads to a decrease in secretion of luteinizing hormone from the pituitary. This in turn leads to a decreased production of estrogen from the ovaries thus impeding the growth of estrogen sensitive tumours.

Endace -40Mg Tablet should not be taken while pregnant or breastfeeding as it may cause harm to the fetus. It should also be avoided if you are allergic to any of its active ingredients or are taking the medication Indinavir (Crixivan).

Some of the most common side effects of the drug include nausea, weight gain, dizziness, difficulty falling asleep, excessive flatulence, spotting in between menstrual cycles and edema. Very high dosages of Endace -40Mg Tablet can lead to symptoms of hypogonadism including decreased secondary sexual characteristics, osteoporosis, and infertility. In severe cases, it may lead to blood clots, diabetes, venous thrombosis, but such cases are rare.

Information given here is based on the salt and content of the medicine. Effect and uses of medicine may vary from person to person. It is advicable to consult a Oncologist before using this medicine.

Endace 40 mg Uses?

• Anorexia Nervosa

The oral suspension form of this medicine is used to treat anorexia nervosa, an eating disorder characterized by low body weight and a fear of gaining weight.

• Cachexia

The oral suspension form of this medicine is used to treat extreme weight loss and muscle wasting caused due to severe chronic illness like acquired immunodeficiency syndrome (AIDS).

• Breast cancer

The oral tablet form of this medicine is used in the palliative treatment of advanced breast cancer.

• Endometrial cancer

The oral tablet form of this medicine is used in the palliative treatment of endometrial cancer, a type of cancer that arose from the lining of the uterus.

• Unexplained Weight Loss

The oral suspension form of this medicine is used in the treatment of weight loss in patients with acquired immunodeficiency syndrome (AIDS)

How Dose Endace 40 mg work?

Endace 40 Tablet is a progestin (female hormone). It works in patients with breast cancer and endometrial cancer by affecting female hormones involved in cancer growth. It causes weight gain by increasing appetite.

How to take Endace 40 mg?

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Endace 40 Tablet may be taken with or without food, but it is better to take it at a fixed time.

Endace 40 mg Contraindications:

• Allergy

This medicine is not recommended for use in patients with a known allergy to megestrol acetate or any other inactive ingredients present along with it.

Endace 40 mg Dosage:

• Missed Dose

Take/consume the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

• Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.

What are the Side effects Of Endace 40 mg?

• Sleeplessness
• Rash
• Sweating
• Diarrhea
• Indigestion
• Mood swings
• Weight gain
• Nausea
• Vomiting
• Increase in blood pressure
• Increased thirst