Xtane 25mg

What is Xtane 25 mg?

Xtane (Exemestane tablets) is used to treat early breast cancer in postmenopausal women who are diagnosed with breast cancer and who have already been treated with a medication called Tamoxifen (Nolvadex) for 2 to 3 years.

Xtane is a brand name of exemestane. Also know as generic Aromasin and it is manufactured by Natco Pharma Limited. Its main use is to treat Breast cancer in women.

Exemestane belongs to a class of medications called aromatase inhibitors. It works by reducing the amount of estrogen produced by the body. This can slow or stop the growth of some breast tumors that require estrogen to grow. Xtane tablets are manufactured by Natco Pharma Limited, India in the strengths of 25 mg.

Xtane 25Mg Tablet is a medication prescribed for the treatment of breast cancer. Xtane 25Mg Tablet belongs to a family of anti-estrogens and is mostly used to arrest the synthesis of estrogen by the release of an enzyme known as aromatase. Certain types of breast cancer are ER-positive and have estrogen receptors that require estrogen to grow and spread. Therefore it is important to lower the estrogen levels to decelerate the spread of the hormone-responsive cancer. The drug may also be used to treat advanced stages of breast cancer in postmenopausal women, where there has been a consistent progress in the disease following tamoxifen therapy.

Xtane 25Mg Tablet is mostly used to treat women who have reached menopausal years, with early symptoms of hormone-receptor-positive breast cancer. However the medication is contraindicated in pregnant, premenopausal or lactating women.

Common side effects of Xtane 25Mg Tablet include severe joint pain, headaches, hot flashes and excessive sweating which are typical symptoms of estrogen deficiency, as caused by the drug. Patients of breast cancer also exhibit symptoms of exhaustion and nausea. Sudden outbreaks of acne or weight gain are also associated with the dosage of the drug. Xtane 25Mg Tablet is known to have androgenic properties like that of formestane, and may also cause a decline in lymphocytes.

Xtane 25 mg Uses

Exemestane is used for the treatment of estrogen-receptor positive breast cancer in postmenopausal women, following 2 to 3 years of tamoxifen therapy. It is also used in later stages of estrogen-receptor positive breast cancer or advanced breast cancer in postmenopausal women who does not respond to an anti-estrogen therapy earlier.

Xtane is an aromatase inhibitor which is used for the adjuvant treatment of postmenopausal women with estrogen-receptor positive early breast cancer who have received two to three years of Tamoxifen and are switched to Xtane for completion of a total of five consecutive years of adjuvant hormonal therapy. It is also used for the treatment of advanced breast cancer in postmenopausal women whose disease has progressed following Tamoxifen therapy.

How does Xtane 25 mg work?

Exemestane is an anti-cancer drug which belongs to the class, steroidal aromatase inhibitors. It works by inhibiting aromatase that are responsible for converting other hormones in the body called androgens to estrogens, thereby reducing the amounts of estrogen in the body which leads to slow down or stops the growth of breast tumors that need estrogen to grow.

Xtane 25 mg Contraindications

Xtane Tablets are contraindicated in patients with a hypersensitivity to Exemestane or any other ingredient present in Xtane tablets. They are also contraindicated in in pregnant or lactating women or women of premenopausal endocrine status.

Xtane 25 mg Dosage

• Missed Dose:

If you miss a dose of Exemestane, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

• Overdose:

During clinical trials Exemestane has been administered as a single dose to healthy female volunteers at doses as high as 800 mg and postmenopausal women with advanced breast cancer have been administered doses as high as 600 mg daily for 12 weeks. These dosages were well tolerated. There is no specific antidote to overdosage and treatment should be symptomatic. General supportive care, including frequent monitoring of vital signs and close observation of the patient, is recommended.

Generic Exemestane Tablets Overdosage

During clinical trials Exemestane has been administered as a single dose to healthy female volunteers at doses as high as 800 mg and postmenopausal women with advanced breast cancer have been administered doses as high as 600 mg daily for 12 weeks. These dosages were well tolerated. There is no specific antidote to overdosage and treatment should be symptomatic. General supportive care, including frequent monitoring of vital signs and close observation of the patient, is recommended.

What are the Side effects of Xtane 25 mg?

• Depression
• Difficulty sleeping
• Headache
• Hot flushes
• Dizziness
• Feeling sick
• Increased sweating
• Muscle and joint pain (including osteoarthritis, back pain, arthritis and joint stiffness)
• Tiredness
• A reduction in the number of white blood cells
• Abdominal pain
• Elevated level of liver enzymes
• Elevated level of a hemoglobin breakdown in the blood
• Elevated level of a blood enzyme in the blood due to liver damage
• Pain

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References:

DailyMed: Exemestane tablet, film coated [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 29 August 2017]. Available from: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3573e3c9-ca05-413f-909f-93607a2ccb79

Exemestane: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 29 August 2017]. Available from: https://medlineplus.gov/druginfo/meds/a607006.html

Exemestane: DrugBank [Internet]. Drugbank.ca. 2017 [cited 29 August 2017]. Available from: https://www.drugbank.ca/drugs/DB00990

[Internet]. 2017 [cited 29 August 2017]. Available from: https://www.medicines.org.uk/emc/PIL.9236.latest.pdf

Exemestane [Internet]. Snomedbrowser.com. 2017 [cited 29 August 2017]. Available from: http://www.snomedbrowser.com/Codes/Details/387017005

What is Prohibited [Internet]. World Anti-Doping Agency. 2017 [cited 29 August 2017]. Available from: https://www.wada-ama.org/en/prohibited-list/prohibited-at-all-times/hormone-and-metabolic-modulators

FAQ:

1. Is exemestane safe during pregnancy?

Exemestane should not be used during pregnancy. Studies of exemestane in animals and pregnant women have shown high risk to fetus. The risk of exemestane use in pregnant women clearly outweighs the benefit.

2. Is exemestane safe during breast feeding?

It is not known if exemestane passes into human breast milk and its effects on the infant are not clear. Exemestane should not be used during breast feeding.

3. Is exemestane a std/ contains stds? Is exemestane a chemo drug?

Exemestane is an anti-cancer drug used in the chemotherapy of estrogen-receptor positive breast cancer (breast tumors that need estrogen to grow) in postmenopausal women. It has a st***dal structure and inhibits hormone aromatase in the body.

4. Is exemestane safe?

Exemestane is relatively safe if used at prescribed doses for the prescribed duration as advised by your doctor.

5. Does exemestane cause hair loss/ diarrhea/ depression/ osteoporosis?

Hair loss (alopecia), diarrhea, depression, thinning and weakening of bones (osteoporosis) are among the known side effects of exemestane.

6. Generic Exemestane Tablets Overdosage

During clinical trials Exemestane has been administered as a single dose to healthy female volunteers at doses as high as 800 mg and postmenopausal women with advanced breast cancer have been administered doses as high as 600 mg daily for 12 weeks. These dosages were well tolerated. There is no specific antidote to overdosage and treatment should be symptomatic. General supportive care, including frequent monitoring of vital signs and close observation of the patient, is recommended.