Progynova 1mg Tablet

About

Progynova tablets 1mg are a hormone replacement therapy (HRT) used to substitute for a lack of oestrogen production by the ovaries that happens during menopause or following surgical removal of the ovaries.

Progynova tablets 1mg help relieve symptoms of menopause caused by oestrogen deficiency, such as hot flushes, night sweats, sleeplessness, vaginal dryness, headaches, mood swings, lack of concentration and loss of energy.

Progynova tablets 1mg can be used alone or in combination with a progestogen in women with an intact uterus.  Progynova tablets 1mg are also used to help prevent postmenopausal bone loss (osteoporosis) and reduce risk of fracture.

Progynova stimulates the development of female sexual characteristics, and is used as the oestrogen component of transgender hormone therapy for male to female transsexuals.

Uses:

Progynova 1mg Tablet is used for hormone replacement therapy, post menopausal osteoporosis and contraception.

How to work?

Progynova 1mg Tablet is a form of estrogen, a female sex hormone produced by the ovaries. It acts by replacing the natural hormone in the body when the latter is deficient.

How to take?

Take one tablet at the same time each day. Taking it at the same time each day will have the best effect. It will also help you remember when to take it. It does not matter if you take this medicine before or after food.

When you have finished each blister foil start the next one on the following day. Never leave a break between blister foils unless your doctor has advised you to. Tablet taking should be continuous.

Contraindications:

Progynova tablets are contraindicated in patients with a hypersensitivity to Estradiol Valerate or any inactive ingredient present in Progynova tablets. Progynova tablets are also contraindicated in the following cases:

• Pregnancy or lactation
• Undiagnosed vaginal bleeding
• Known or suspected cancer of the breast
• Known or suspected premalignant conditions or malignancies, if sex steroid-influenced
• Presence or history of liver tumours (benign or malignant)
• Severe hepatic disease
• Acute arterial thromboembolism (myocardial infarction, stroke) or a recent history of these conditions
• Active deep venous thrombosis, thromboembolic disorders, thrombophlebitis, or a documented history of these conditions
• A high risk of venous or arterial thrombosis
• Hereditary or acquired predisposition to venous thrombosis (e.g. antithrombin III deficiency)
• Severe hypertriglyceridamia

Dosage:

When estrogen (Progynova tablets) is prescribed for a postmenopausal woman with a uterus, a progestin should also be initiated to reduce the risk of endometrial cancer. A woman without a uterus does not need progestin. The dosage of Progynova (Estradiol Valerate Tablets) for various indications is given below.

Side effects:

A feeling of tension in the breasts, gastric upsets, nausea and vomiting, headaches, increase in body weight, and uterine bleeding can occur.

The doctor should be informed if other medical preparations are taken regularly (eg barbiturates, phenylbutazone, hydantoins, rifampicin, ampicillin) since they can impair the action of Progynova.

If uterine bleeding occurs, the patient must consult her doctor in order to clarify the cause.

Gynaecological check-ups should be carried out at about 6-month intervals.

The doctor should be informed if the patient suffers from the following disorders: diabetes, high blood pressure, varicose veins, otosclerosis, multiple sclerosis, epilepsy, porphyria, tetany, chorea minor. In all these cases, and also where there is a history of phlebitis, strict medical supervision is necessary.

Warnings:

Alcohol

Interaction with alcohol is unknown. Please consult your doctor

Pregnancy

Progynova 1mg Tablet is highly unsafe to use during pregnancy.

Human and animal studies have shown significant adverse effects on the foetus. Please consult your doctor.

Lactation

Progynova 1mg Tablet is probably safe to use during lactation. Limited human data suggests that the drug does not represent a significant risk to the baby.

Driving

Progynova 1mg Tablet does not usually affect your ability to drive.

Kidney

Progynova 1mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Progynova 1mg Tablet may be needed. Please consult your doctor.

Liver

Progynova 1mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Progynova 1mg Tablet may be needed. Please consult your doctor.

Use of Progynova 1mg Tablet is not recommended in patients who previously had liver disease and the liver function tests are still not normal.

References:

Estradiol | C18H24O2 – PubChem [Internet]. Pubchem.ncbi.nlm.nih.gov. 2017 [cited 19 April 2017]. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/5757#section=Top

Estradiol: Side Effects, Dosage, Uses [Internet]. Healthline.com. 2017 [cited 19 April 2017]. Available from: http://www.healthline.com/drugs/estradiol/oral-tablet#Highlights1

Estrogen Injection: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 19 April 2017]. Available from: https://medlineplus.gov/druginfo/meds/a606004.html

DrugBank [Internet]. Drugbank.ca. 2017 [cited 16 November 2017]. Available from: https://www.drugbank.ca/unearth/q?utf8=%E2%9C%93&query=estradiol&searcher=drugs

FAQ:

1.Is estradiol and estrogen the same/ is estradiol the same as progesterone/ is estradiol a synthetic hormone/does estradiol valerate work/ what is evalon cream?

Estradiol is the most potent natural estrogen (or “estrogen”) produced by ovaries in female. It is different from another female hormone that is progesterone.

It is not a conjugated estrogen and it not a synthetic hormone. Estradiol valerate and Evalon vaginal cream works same as estradiol

2.Can I take estrogen for polycystic ovary syndrome (PCOS)?

Polycystic ovary syndrome (PCOS) is mainly a result of hormonal disturbance in which there are high levels of male hormones in the body.

Oral contraceptive pills containing low dose estrogen and progestogen are commonly prescribed to reduce the levels of endogenous hormone, which helps regularize the menstrual cycle, reduce male hormone levels and decrease acne associated with PCOS. Always consult your doctor before using any medication

3.What can I take for estrogen dominance?

A balanced diet, exercise, a healthy life style and less exposure to environmental pollutants is what works best to restore the normal hormone balance and reduce estrogen dominance.

Your doctor may also start a progesterone therapy, compounds that promote bile secretion, lipotropic formulas (excrete extra estrogen from body), substance which deactivate toxic substances and excess hormones to remove extra estrogen from your body

4.What can I take for estrogen deficiency?

For estrogen deficiency, treatment is based on the underlying cause. Your doctor may choose from a variety of medications depending upon your condition for e.g.

young or old with menopause, estrogen deficiency or high progesterone levels, etc. You may be given bio-identical estradiol or estriol or counterbalance with natural progesterone in the form of micronized capsules, etc