Veenat 400mg

What is Veenat 400 mg?

Veenat 400 mg Tablet is used to treat and prevent the growth of certain types of cancers of the blood cells, stomach, intestine, bone marrow, and skin. Imatinib Mesylate is a targeted therapy.

Imatinib Mesylate is classified as a signal transduction inhibitor – protein-tyrosine kinase inhibitor. Imatinib mesylate belongs to the signal transduction inhibitor category of targeted therapies.  It is particularly a protein-tyrosine kinase inhibitor.

Veenat may also be used to prevent cancer from growing in patients after surgical removal of gist. Veenat is also used for the treatment of dermatofibrosarcoma protuberans. when the tumor cannot be removed surgically, has spread to other parts of the body, or has come back after surgery. It is also used to treat mastocytosis (a buildup of large amounts of mast cells in certain parts of the body).

How to Uses Veenat 400 mg?

Generic Imatinib Tablets (Veenat by Natco) is utilized to treat certain types of leukemia in adult and pediatric sick person. Generic Imatinib is also utilized to treat gastrointestinal stromal tumours(GIST), a type of tumor most often found in the wall of the stomach. This medication is also used to treat Dermatofibrosarcoma Protuberans (DFSP) a rare type of cancer that occurs in the deep layers of skin in adult patients.

How does Veenat 400 mg work?

Veenat 400mg Tablet is an anti-cancer medication. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.

This tablet (Veenat) is a tyrosine kinase inhibitor. Tyrosine kinases are important proteins in the body that regulate how cells grow and divide. Imatinib cancer medication blocks the activity of this enzyme, which delivers a signal that causes cells to multiply.

How to take Veenat 400 mg?

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Veenat 400mg Tablet is to be taken with food.

Veenat 400 mg Contraindications

Veenat tablets are contraindicated in patients with a hypersensitivity to Imatinib Mesylate or any inactive ingredient present in Veenat tablets.

Hypersensitivity to Veenat Tablet is a contraindication. In addition, Veenat Tablet should not be used if you have the following conditions:

• Breastfeeding
• Hypersensitivity
• Levothyroxine
• Liver, kidney or heart problems
• Weight gain

Veenat 400 mg Dosage

• Missed Dose:

Take the missed dose as soon as you remember. If it is almost time for the next scheduled dose, then the missed dose can be skipped. Contact your physician for further advice if you miss more than one scheduled dose of this drug.

• Overdose:

Contact your physician immediately if an overdose with this medication is suspected. Symptoms may include nausea, vomiting, diarrhea, skin allergies, tiredness, fever, etc.

What are the Side effects of Veenat 400 mg?

• Diarrhea
• Nausea and Vomiting
• Mouth sores
• Loss of appetite
• Altered sense of taste
• Heartburn and indigestion
• Joint pain, stiffness, and swelling
• Burning or tingling sensation of skin
• Difficulty in falling or staying asleep
• Skin rash, hives, or itching
• Hair loss or thinning of the hair
• Swelling around the eyes
• Swelling or the hands, feet, ankle, and lower legs
• Severe breathing difficulty
• Fast/irregular heart beat
• Presence of blood in cough
• Yellowing of skin and eyes
• Unusual bleeding or bruising
• Abdominal pain or bloating

Warnings:

Edema and severe fluid retention have occurred. Doctors are advised to weigh patients regularly and manage unexpected rapid weight gain by drug interruption and diuretics.

Cytopenias, particularly anemia, neutropenia, and thrombocytopenia, have occurred. Manage with dose reduction or dose interruption and in rare cases discontinuation of treatment. Complete blood counts have to be performed weekly for the first month, biweekly for the second month, and periodically thereafter.

Severe congestive heart failure and left ventricular dysfunction have been reported, specially in patients with comorbidities and risk factors. Monitor and treat patients with cardiac disease or risk factors for cardiac failure.

Severe hepatotoxicity including fatalities can occur. patients must be assessed for liver function before initiation of treatment and monthly thereafter or as clinically indicated.

Grade 3/4 hemorrhage has been reported in clinical studies in patients with newly diagnosed CML and with GIST. GI tumor sites may be the source of GI bleeds in GIST.

References:

Imatinib: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 13 September 2017]. Available from: https://medlineplus.gov/druginfo/meds/a606018.html

Imatinib mesylate [Internet]. Pubchem.ncbi.nlm.nih.gov. 2017 [cited 13 September 2017]. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/123596

FAQ:

1. How long can I use Imatinib medicine?

You should use Imatinib medicine for a prescribed duration. Do not discontinue the drug unless recommended by the doctor.

2. Is it safe to alter the dose of Imatinib medicine?

Do not alter the dose of Imatinib medicine without consulting the doctor. A change in the medicine dose may fail to produce drug action.

3. What are the other formulations of Imatinib medicine available?

Imatinib medicine is also available in capsule form.