Hepcinat (Sofosbuvir 400mg)

What is Hepcinat?

Hepcinat (Sofosbuvir 400 mg) is a generic version of Sovaldi Tablets. Hepcinat contains the same active ingridient Sofosbuvir 400 mg which allows most patients to be cured without the use of peginterferon. Hepcinat (Sofosbuvir 400mg) tablets cost very less rate which is 50 times less comparing to branded version Sovaldi  (Sofosbuvir)

Sofosbuvir is a medication used to treat Hep C. Available in India as under brand name Hapcinat Tablets. It is to used cure people of the Hep C virus alongwith combination of other medications (peginterferon alfa and ribavirin, or ribavirin alone). Hapcinat is taken at a dose of 400 mg once per day. It doesn’t need to be taken with food. So far, sofosbuvir appears to have few side effects. Common side effects of treatment are associated with the other medications sofosbuvir is taken with. Hep C treatment can cure a person from Hep C. However, a person could be infected again.

Hepcinat Uses?

Sofosbuvir is used in combination with other antiviral drugs for treatment of patients with viral infection that damages the liver (Hepatitis C) including those patients who have human immunodeficiency virus (HIV) infection or liver cancer or are awaiting a liver transplant.

Hepcinat (Sofosbuvir 400mg) Tablets are the orally administered medicament taken one time per day unless otherwise recommended by a doctor. The tablets can be taken with food or without food but at the same time every day. Ask the doctor for the correct dosage and duration of treatment.

How does Hepcinat work?

Hepcinat (Sofosbuvir) is a generic version of Generic Sofosbuvir. Sofosbuvir is the breakthrough treatments for Hepatitis C infections. Its works by inhibiting the enzyme which is necessary for the virus if it is to multiply. A complete cure may even be possible. Chronic hepatitis C is a serious infection of the liver which occurs following an infection with the hepatitis C virus. Upon reaching the cells of the liver, the virus begins to multiply, which it achieves by means of copying its DNA and RNA.

This medicine is known as a nucleotide polymerase inhibitor, and it works directly on the virus itself. After oral administration, it undergoes a process of intracellular metabolism in which it is converted to its active form. It subsequently starts to work, whereupon it actively targets the enzyme that is used by the virus to produce RNA chains (HCV NS5B RNA-dependent RNA polymerase). This can help to stop viral multiplication. Treatment of genotypes 1, 2, 3 and 4 is possible with this medicine, however it is always used in combination with other medications and never on its own.

How to take Hepcinat?

HEPCINAT 400mg dose should be taken at a fixed time as directed by your doctor. You should swallow the tablet as a whole with water. Do not chew or crush it. It is better to take it with food.

Hepcinat Contraindications:

Care should be taken in hypersensitivity (Allergy) and other Liver Disorders. You should monitor Liver Function Test regularly. HEPCINAT 400 mg should be taken as prescribed by your doctor. Do not stop taking this tablet before completion of the course.

Hepcinat Dosage:

• Missed Dose:

If a dose of Hepcinat 400 mg Tablet is missed, take the dose as soon as you remember it. If it almost time for the next dose, then skip the missed dose. Do not double the dose to make up for the missed one.

• Overdose:

Seek emergency medical treatment or contact the doctor in case of an overdose.

What are the Side effects of Hepcinat?

Patients using Hepcinat Hepcinat (Sofosbuvir 400mg) may meet some unwanted side effects of the mediacte such as:

• Headaches
• Diarrhea
• Lower back or side pain
• Loss of appetite
• Sleep disorder
• Fever

Hepcinat Warnings?

This medicine should be used with extreme caution in combination with amiodarone due to the increased risk of life-threatening cardiac complications including fatal cardiac arrest. This risk is especially higher in the first 48 hours of starting treatment with both these medicines. Coadministration of these medicines should be done only under close medical supervision with provisions to continuously monitor all vital signs of the patient. Replacement with a suitable alternative may be done based on the clinical condition of the patient.

Hepcinat must not be taken by a pregnant or breastfeeding woman.

References:

[Internet]. 2017 [cited 9 August 2017]. Available from: https://www.medicines.org.uk/emc/medicine/28539

Sofosbuvir: Sofosbuvir tablet, film coated [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 9 August 2017]. Available from: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=80beab2c-396e-4a37-a4dc-40fdb62859cf

Prescribing medicines in pregnancy database [Internet]. Therapeutic Goods Administration (TGA). 2017 [cited 9 August 2017]. Available from: http://www.tga.gov.au/prescribing-medicines-pregnancy-database

Sofosbuvir – DrugBank [Internet]. Drugbank.ca. 2017 [cited 9 August 2017]. Available from: https://www.drugbank.ca/drugs/DB08934

FAQ:

1. Is sofosbuvir safe in pregnancy?

Sofosbuvir should not be used in pregnancy or by those who plan to become pregnant as it is highly unsafe for the growing baby.

2. Is it safe to use sofosbuvir during breastfeeding?

Sofosbuvir is not safe for the baby and should not be used by women who are breastfeeding.

3. Is Sofosbuvir a protease inhibitor? How does Sofosbuvir work?

No. Sofosbuvir is a nucleotide polymerase inhibitor which stops viral replication and thus decreases the amount of Hepatitis C virus in the body thereby resulting in less liver damage and improved liver function.

4. Does Sofosbuvir cure Hepatitis C?

Sofosbuvir is used to treat Hepatitis C virus infection. The treatment response with Sofosbuvir (in conjunction with other drugs) varies based on baseline host and viral factors.