Premarin 0.625mg Tablet is a female sex hormone responsible for regulation and development of the female reproductive system. It is used in Hormone Replacement Therapy for hypogonadal, postmenopausal, and transgender women; as medications in oral contraceptives, and in the treatment of hormone sensitive cancers like breast cacer, prostate cancer.
It is recommended that you should not take Premarin 0.625mg Tablet if you are pregnant or plan on becoming pregnant, or you are breastfeeding; or if you have a condition or history of liver disease, blood clotting, stroke or heart attack, or if you are allergic to any medicines. It should only be taken for HRT and in treament of certain cancers only if it is prescribed by the doctor.
The use of Premarin 0.625mg Tablet is associated with increased risk of blood clotting, cardiovascular disease, stroke, uterine cancer or breast cancer.
Premarin 0.625mg Tablet can be taken orally, vaginally, topically, or via injection. It should be taken only as per the prescribed dosage given by the doctor according to your conditions.
Premarin Conjugated Estrogens tablets are a mixture of estrogen hormones used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Estrogen is a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body.
Other uses include prevention of osteoporosis in postmenopausal women, and replacement of estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. Premarin (Conjugated Estrogens) is sometimes used as part of cancer treatment in women and men.
We supply original brand Premarin manufactured by Pfizer at their sister company Wyeth.
How to work?
Premarin 0.625mg Tablet is a primary female sex hormone that, as a part of the hormone replacement therapy, works by maintaining the estrogen levels in the body, thereby relieving the symptoms occurring after menopause.
How to take?
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it.
Premarin tablets (Conjugated Estrogens) are contraindicated in patients that have one or more of the following medical conditions:
- Hypersensitivity to Conjugated Estrogens or to any inactive ingredient present in Premarin tablets.
- Liver dysfunction or disease
- Known or suspected estrogen-dependent malignant neoplasia
- Endometrial hyperplasia, Known, suspected, or past history of breast cancer
- Undiagnosed abnormal genital bleeding
- Known or suspected pregnancy
- Active or past history of confirmed venous thromboembolism or active thrombophlebitis
- Active or past history of arterial thromboembolic disease
- Partial or complete loss of vision due to ophthalmic vascular disease
- Migraine with aura
The recommended dosage of Premarin tablets varies as per the medical condition being treated.
The recommended dosage is 0.625 mg to 1.25 mg daily, which has to be adjusted upward or downward according to severity of symptoms and response of the patient.
Osteoporosis (loss of bone mass):
The recommended dosage is 0.625 mg daily.
Hypoestrogenism due to Female Hypogonadism:
The recommended dosage of Conjugated Estrogens tablets is 0.3 mg to 0.625 mg daily, administered cyclically (e.g., 3 weeks on and 1 week off) or continuously as required. Doses are adjusted depending on the severity of symptoms and responsiveness of the endometrium.
Hypoestrogenism due to Female castration or primary ovarian failure:
The recommended dosage of Conjugated Estrogens is 1.25 mg daily, cyclically or continuously as required. The dosage has to be adjusted upward or downward according to severity of symptoms and response of the patient. For maintenance, adjust dosage to lowest level that will provide effective control.
Atrophic Vaginitis or Vulvar Atrophy:
The recommended dosage is 0.3 mg to 1.25 mg daily depending upon the tissue response of the individual patient being treated.
In addition to its intended effect, Premarin 0.625Mg Tablet may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.
The most common side effects reported when using Premarin include: nausea, vomiting, bloating, stomach cramps breast pain, tenderness, or swelling, increased hair growth, loss of scalp hair, vaginal itching or discharge, changes in menstrual periods, decreased libido, headache, nervousness, dizziness, tired feeling, freckles or darkening of facial skin, changes in weight or appetite. More severe side effects include changes in liver function at higher doses.
Do not use Premarin Tablets if you have:
- a history of heart attack, stroke, or blood clot (especially in your lung or your lower body)
- abnormal vaginal bleeding that a doctor has not checked
- liver disease
- any type of breast, uterine, or hormone-dependent cancer
Before using this medicine, tell your doctor if you are allergic to any drugs, or if you have:
- high blood pressure, heart disease, or circulation problems
- a personal or family history of stroke
- kidney disease
- epilepsy or other seizure disorder
- underactive thyroid
- high cholesterol or triglycerides
The Writing Group for the PEPI Trial “Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women: the Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial.” JAMA 273 (1995)
Gordeuk VR, Brittenham GM, Hughes M, Keating LJ, Opplt JJ “High-dose carbonyl iron for iron deficiency anemia: a randomized double-blind trial.” Am J Clin Nutr 46 (1987)
Kamali P, Muller T, Lang U, Clapp JF “Cardiovascular responses of perimenopausal women to hormonal replacement therapy.” Am J Obstet Gynecol 182 (2000)
Hulley S, Grady D, Bush T, Furberg C, Herrington D, Riggs B, Vittinghoff E “Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women.” JAMA 280 (1998)
Collins P, Beale CM, Rosano GMC “Oestrogen as a calcium channel blocker.” Eur Heart J 17 ( Suppl (1996)
Herrington DM “The HERS Trial results: paradigms lost?” Ann Intern Med 131 (1999): 463-6
1.Can Conjugated Estrogen be used in the treatment of osteoporosis?
Yes. Conjugated Estrogen can be used in the treatment of osteoporosis when recommended by the doctor.
2.Can I undergo metyrapone test while using Conjugated Estrogen?
No. It is advisable not to use Conjugated Estrogen as it alters the test result. However, please consult your doctor.
3.Is it safe to use Conjugated Estrogen in patients having a history of deep vein thrombosis?
No. It is unsafe to use Conjugated Estrogen in patients having a history of deep vein thrombosis, as it increases the risk of blood clot.
4.What precautions do I need to take while using Conjugated Estrogen?
Conjugated Estrogen causes blotchy and dark areas on the skin, so avoid excessive exposure to the sun. Use sunscreen and wear protective clothing while using Conjugated Estrogen.