Progynova 2mg Tablet

About

Progynova 2mg Tablet is a female estrogen hormone that is prescribed to treat menopause symptoms such as hot flashes, night sweats, vaginal dryness/itching, irregular periods, and mood swings. Besides, this medication prevents bone fractures (osteoporosis) and reduces the risk of heart attacks.

Progynova 2mg Tablet vaginal cream is indicated for vaginal atrophy associated with menopause. This medicine may also be used to treat other conditions as determined by your doctor.

Uses:

Progynova 2 mg tablets are a hormone replacement therapy (HRT) used as an alternative for a lack of oestrogen production by the ovaries that happens during menopause or following surgical removal of the ovaries, to relieve symptoms of menopause caused by oestrogen deficiency, such as restlessness, night mare, headache, hot flushes, vaginal dryness, mood swings, lack of concentration and loss of energy.

The tablets are also used to help in prevention of postmenopausal bone loss (osteoporosis) and decrease the risk of fracture. The medication stimulates the improvement of female sexual characteristics, and is used as the oestrogen component of transgender hormone therapy for masculine to feminine transsexuals. 

How to work?

Progynova 2mg Tablet is a form of estrogen, a female sex hormone produced by the ovaries. It acts by replacing the natural hormone in the body when the latter is deficient.

Contraindications:

• Known, past or suspected breast cancer
• Known or suspected oestrogen-dependent malignant tumours e.g. endometrial cancer
• Undiagnosed genital bleeding
• Untreated endometrial hyperplasia
• Previous idiopathic or current venous thromboembolism (deep venous thrombosis, pulmonary embolism)
• Known thrombophilic disorders (e.g. protein C, protein S, or antithrombin deficiency, see section 4.4)
• Active or recent arterial thromboembolic disease e.g. angina, myocardial infarction
• Acute liver disease, or a history of liver disease as long as liver function tests have failed to return to normal
• Hypersensitivity to the active substances or to any of the excipients listed in section 6.1
• Porphyria

Dosage:

If this is your first HRT treatment and you are still having regular periods: start your Estradiol valerate tablets on the first day of bleeding If this is your first HRT treatment and your periods have become very infrequent or have stopped completely: you can start your Estradiol valerate tablets at any time if you sure you are not pregnant. If you take more Estradiol valerate than you should.

Side effects:

• Breast pain and tenderness
• Vomiting
• Weight gain
• Dizziness
• Depression
• Back pain
• Headache
• Vaginal discharge with no odor
• Flu like symptoms
• Excessive vaginal bleeding
• Swelling of face, lips, eyelids, tongue, hands and feet
• Troubled breathing and swallowing
• Discharge from the nipple
• Change in the texture of breast skin and nipples
• Inverted nipples

Warnings:

Warnings for special population

Pregnancy

Use of this medicine is not recommended if you are pregnant or planning a pregnancy in immediate future. Contact your doctor if you suspect a pregnancy while being treated with this medicine.

Breast-feeding

This medicine should be used with caution in women who are breastfeeding. Consult your doctor before using this medicine.

General warnings

Abnormal vaginal bleeding

This medicine should not be given to women having undiagnosed abnormal vaginal bleeding. Appropriate tests should be performed to rule out cancer in all cases of abnormal and persistent bleeding before treatment with estradiol is initiated.

Cardiovascular risks

This medicine has been associated with an increased risk of stroke, heart attack, and other complications associated with the heart. It should be used with caution in patients having a heart disease or are exposed to the risk factors.

Dementia

This medicine has been associated with an increased risk of dementia especially in the elderly. Caution is advised if this medicine is used in the elderly for longer durations.

Breast cancer

Use of this medicine increases the risks of breast cancer and hence should be used at the lowest doses and the duration of treatment should be kept as low as possible.

Jaundice like symptoms

Use of this medicine can cause yellowing of the eyes and skin due to its effect on the liver and the gall bladder. Report the presence of any symptom indicative of jaundice to the doctor on priority. Use of this medicine should be stopped in such cases.

References:

Estradiol | C18H24O2 – PubChem [Internet]. Pubchem.ncbi.nlm.nih.gov. 2017 [cited 19 April 2017]. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/5757#section=Top

Estradiol: Side Effects, Dosage, Uses [Internet]. Healthline.com. 2017 [cited 19 April 2017]. Available from: http://www.healthline.com/drugs/estradiol/oral-tablet#Highlights1

Estrogen Injection: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 19 April 2017]. Available from: https://medlineplus.gov/druginfo/meds/a606004.html

DrugBank [Internet]. Drugbank.ca. 2017 [cited 16 November 2017]. Available from: https://www.drugbank.ca/unearth/q?utf8=%E2%9C%93&query=estradiol&searcher=drugs

FAQ:

1.Is estradiol and estrogen the same/ is estradiol the same as progesterone/ is estradiol a synthetic hormone/does estradiol valerate work/ what is evalon cream?

Estradiol is the most potent natural estrogen (or “estrogen”) produced by ovaries in female. It is different from another female hormone that is progesterone.

It is not a conjugated estrogen and it not a synthetic hormone. Estradiol valerate and Evalon vaginal cream works same as estradiol

2.Can I take estrogen for polycystic ovary syndrome (PCOS)?

Polycystic ovary syndrome (PCOS) is mainly a result of hormonal disturbance in which there are high levels of male hormones in the body.

Oral contraceptive pills containing low dose estrogen and progestogen are commonly prescribed to reduce the levels of endogenous hormone, which helps regularize the menstrual cycle, reduce male hormone levels and decrease acne associated with PCOS. Always consult your doctor before using any medication

3.What can I take for estrogen dominance?

A balanced diet, exercise, a healthy life style and less exposure to environmental pollutants is what works best to restore the normal hormone balance and reduce estrogen dominance.

Your doctor may also start a progesterone therapy, compounds that promote bile secretion, lipotropic formulas (excrete extra estrogen from body), substance which deactivate toxic substances and excess hormones to remove extra estrogen from your body

4.What can I take for estrogen deficiency?

For estrogen deficiency, treatment is based on the underlying cause. Your doctor may choose from a variety of medications depending upon your condition for e.g. young or old with menopause, estrogen deficiency or high progesterone levels, etc. You may be given bio-identical estradiol or estriol or counterbalance with natural progesterone in the form of micronized capsules, etc