Premarin Vaginal Cream contains a mixture of estrogen hormones. Estrogen is a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body. Conjugated estrogens are a mixture of estrogen hormones.
Premarin Vaginal Cream is used in the vagina to treat the vaginal symptoms of menopause such as dryness, burning, irritation, and painful erotic intercourse. Premarin Vaginal may also be used for purposes not listed in this medication guide.
Premarin Cream is used to treat menopausal changes in and around the vagina, caused by a lack of oestrogen production by the ovaries. Premarin Cream is a short-term hormone replacement therapy (HRT) used to treat atrophic vaginitis (also called vaginal atrophy), which occurs when tissues in and around the vagina become thinner and less elastic and produce less lubrication, causing symptoms of dryness burning and itching around the vagina, which can also lead to inflammation in the vaginal tissues.
Changes in the skin of the vagina can lead to sex being uncomfortable or painful, and to an increased susceptibility to vaginal or urinary infections, also mild urinary incontinence. Premarin cream provides a topical oestrogen treatment that helps to restore the vaginal tissue, by treating the underlying cause, which reduces symptoms and prevents recurrent infections.
How to work?
Premarin cream contains conjugated oestrogens, which is a mixture of natural oestrogens isolated exclusively from natural sources. Oestrogen is a steroid hormone produced by the ovaries that binds to specific receptors inside oestrogen-responsive cells and stimulates them to make proteins involved in producing secondary sexual characteristics, including thickening of the vaginal wall and increasing vaginal secretion.
When Premarin cream is inserted into the vagina, oestrogen is slowly released and absorbed into the vaginal skin layer where it reverses changes in the vagina by stimulating thickening of the skin, reducing inflammation and restoring the physiological pH and normal microflora (the “good” bacteria that normally live in the skin and increases resistance to infection with other bacteria that cause vaginal or urinary infections).
The restoring effect of Premarin cream reduces symptoms of atrophic vaginitis which can be maintained with continued use.
How to take?
Premarin cream is intended for short-term use until symptoms of atrophic vaginitis improve. You should use Premarin cream for as long as recommended by your doctor, which may be for a few days or a few months. If you are using Premarin cream for a month or more, you should use it for three weeks and then stop using it for one week.
PREMARIN therapy is contraindicated in individuals with any of the following conditions:
- Undiagnosed abnormal genital bleeding
- Known, suspected, or history of breast cancer except in appropriately selected patients being treated for metastatic disease
- Known or suspected estrogen-dependent neoplasia
- Active DVT, PE, or a history of these conditions
- Active arterial thromboembolic disease (for example stroke and MI), or a history of these conditions
- Known anaphylactic reaction or angioedema with Premarin
- Known liver impairment or disease
- Known protein C, protein S or antithrombin deficiency, or other known thrombophilic disorders.
- Known or suspected pregnancy
This medicine may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe nausea/vomiting, unusual vaginal bleeding.
Nausea/vomiting, bloating, breast tenderness, headache, or weight changes may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious
Tell your doctor right away if you have any serious side effects, including: mental/mood changes (such as depression, memory loss), breast lumps, unusual vaginal bleeding (such as spotting, breakthrough bleeding, prolonged/recurrent bleeding), increased or new vaginal irritation/itching/odor/discharge, severe stomach/abdominal pain, persistent nausea/vomiting, yellowing eyes/skin, dark urine, swelling hands/ankles/feet, increased thirst/urination.
- Avoid using the medicine if you are allergic to Premarin Vaginal Cream or similar drugs.
- Avoid consumption of alcohol as it may alter the absorption of Premarin Vaginal Cream.
- Do not drive or operate heavy machinery if Premarin Vaginal Cream causes dizziness or blurred vision.
- Avoid Premarin Vaginal Cream during pregnancy or breastfeeding because the safe use of the drug is not yet established.
- Do not stop using the medication abruptly unless instructed by the doctor. Stopping the medication suddenly may cause the illness to return.
- Do not exceed the dose prescribed by the doctor.
- You are advised not to use Premarin Vaginal Cream if
- it has passed the expiry date of the medicine printed on the pack.
- the foil or packaging is torn or shows signs of tampering or there is discolouration.
Rossouw JE, et al. Postmenopausal Hormone Therapy and Risk of Cardiovascular Disease by Age and Years Since Menopause. JAMA. 2007;297:1465–1477.
Hsia J, et al. Conjugated Equine Estrogens and Coronary Heart Disease. Arch Int Med. 2006;166:357–365.
Curb JD, et al. Venous Thrombosis and Conjugated Equine Estrogen in Women Without a Uterus. Arch Int Med. 2006;166:772–780.
Cushman M, et al. Estrogen Plus Progestin and Risk of Venous Thrombosis. JAMA. 2004;292:1573–1580.
1.Can Premarin Vaginal Cream be used in the treatment of osteoporosis?
Yes. Premarin Vaginal Cream can be used in the treatment of osteoporosis when recommended by the doctor.
2.Can I undergo metyrapone test while using Premarin Vaginal Cream?
No. It is advisable not to use PREMARIN VAGINAL Cream as it alters the test result. However, please consult your doctor.
3.Is it safe to use Premarin Vaginal Cream in patients having a history of deep vein thrombosis?
No. It is unsafe to use Premarin Vaginal Cream in patients having a history of deep vein thrombosis, as it increases the risk of blood clot.
4.What precautions do I need to take while using Premarin Vaginal Cream?
Premarin Vaginal Cream causes blotchy and dark areas on the skin, so avoid excessive exposure to the sun. Use sunscreen and wear protective clothing while using Premarin Vaginal Cream.
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